Unlocking Wellness: Your Comprehensive Guide to Gut Health Improvement

ByTarquin Reading Time: 19 minutes
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The gut, often referred to as the body’s “second brain,” plays a pivotal role in maintaining overall health. It’s not just responsible for digestion; the gut is a complex system that influences everything from immunity to mood.

At the heart of this system is the gut microbiome, a diverse community of trillions of bacteria that reside in our intestines.

This intricate ecosystem is a delicate balance of beneficial and harmful bacteria. When this balance is disrupted, it can lead to a myriad of health issues, emphasizing the importance of maintaining optimal gut health.

In this comprehensive guide, we’ll delve into the significance of gut health, the wonders of the gut microbiome, and their profound impact on overall well-being.

Key Takeaways
  • Health Foundation: A healthy gut improves nutrient absorption and body functions1.
  • Immunity: Gut health boosts the body’s defenses, as 70% of the immune system is in the gut2.
  • Mental Health: The gut influences mood and can impact conditions like anxiety and depression3.
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Understanding the Basics of Gut Health

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What is the Gut Microbiome?

The gut microbiome refers to the vast and diverse community of microorganisms, including bacteria, fungi, viruses, and other microbes, that reside in our digestive tracts6.

Where is the gut microbiome in your body?

The gut microbiome is located in your digestive tract, primarily in the large intestine, also known as the colon.

This intricate ecosystem plays a pivotal role in various physiological processes, from digestion and nutrient absorption to immune system regulation.

  • Composition: The gut is home to trillions of microbes, with the majority being bacteria. The composition of these bacteria varies among individuals due to factors like diet, genetics, and environment6.
  • Diversity: A healthy gut microbiome is characterized by a rich diversity of microbial species. This diversity ensures resilience against harmful pathogens and efficient nutrient metabolism7.

Role of Gut Bacteria in Health and Disease:

Gut bacteria are not just passive residents; they actively contribute to our health in numerous ways:

  • Digestion: Certain bacteria help break down complex carbohydrates, producing short-chain fatty acids (SCFAs) that nourish the gut lining8.
  • Immunity: Gut bacteria play a crucial role in training our immune system, helping it distinguish between friend and foe7.
  • Mental Health: The bidirectional communication system of the gut-brain axis, suggests that gut bacteria can influence brain function and behavior8.
  • Protection: Beneficial bacteria can outcompete harmful pathogens, preventing infections9.

However, when there’s an imbalance in the gut bacteria, it can lead to various diseases:, including those that affect the large intestine.

  • Digestive Disorders: Conditions like irritable bowel syndrome (IBS) and inflammatory bowel disease (IBD) have been linked to an imbalanced gut microbiome8.
  • Autoimmune Diseases: An imbalanced gut can trigger an overactive immune response, leading to diseases like lupus7.
  • Metabolic Disorders: Obesity, diabetes, and heart disease have also been associated with changes in the gut microbiome10.

Impact of an Imbalanced Gut Microbiome:

An imbalanced gut microbiome, often referred to as “dysbiosis,” can have far-reaching consequences.

  • Digestive Issues: Symptoms like bloating, gas, diarrhea, and constipation can arise8.
  • Weakened Immunity: A lack of beneficial bacteria can make one more susceptible to infections7.
  • Chronic Inflammation: Dysbiosis can lead to a chronic inflammatory state, which is a precursor to many diseases9.
  • Mental Health Concerns: Conditions like anxiety and depression have been linked to gut health8.
what causes dysbiosis?

Dysbiosis can be caused by factors such as poor diet, stress, lack of sleep, antibiotic use, and certain medical conditions.

Recognizing the importance of a balanced gut microbiome and its profound impact on overall health is the first step towards making informed choices for better gut health.

Factors Affecting Your Gut Health

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The Role of Diet in Gut Health:

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Fiber-Rich Foods

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Probiotic and Prebiotic Foods

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Processed Foods

Diet is one of the most influential factors in shaping the composition and function of the gut microbiome. The type of fiber in the food we consume serves as the primary source of energy and nutrients for the gut bacteria11.

Seeking advice from a registered dietitian can help ensure that your diet is balanced and provides the necessary nutrients for a healthy gut microbiome.

  • Fiber-Rich Foods: Dietary fiber, found in fruits, vegetables, and whole grains, is fermented by gut bacteria into short-chain fatty acids (SCFAs). SCFAs nourish the gut lining and have anti-inflammatory properties11.
  • Probiotic and Prebiotic Foods: Probiotics (live beneficial bacteria) and prebiotics (food for these bacteria) can help maintain a healthy gut microbiome. Foods like yogurt, kefir, and sauerkraut are rich in probiotics, while onions, garlic, and bananas are good sources of prebiotics11.
  • Processed Foods: Diets high in processed foods and sugars can disrupt the balance of the gut microbiome, leading to dysbiosis12.

How Lifestyle Factors Like Exercise and Sleep Affect Gut Health:

Lifestyle factors, including physical activity and sleep, play a significant role in gut health.

  • Exercise: Regular physical activity can enhance the diversity of the gut microbiome. It can also stimulate the production of SCFAs, promoting gut health and reducing inflammation13.
  • Sleep: Quality and quantity of sleep can influence the gut microbiome. Sleep deprivation or irregular sleep patterns can disrupt the gut microbiome, potentially leading to dysbiosis14.

The Impact of Stress on Gut Health:

Stress, whether physical or emotional, can significantly impact gut health.

  • Stress Response: Stress can trigger a response that disrupts the balance of the gut microbiome, leading to dysbiosis. This can further exacerbate the body’s stress response, creating a vicious cycle11.
  • Gut-Brain Axis: The gut and brain communicate bidirectionally, referred to as the gut-brain axis. Stress can disrupt this communication, affecting both gut health and mental well-being11.
Where does physical or emotional stress come from?

Physical stress comes from things like lack of sleep, illness, or hard exercise. Emotional stress comes from difficult life situations like work pressure or personal problems.

Factors Affecting Gut Health

FactorsImpact on Gut Health
DietDirectly influences the composition and function of the gut microbiome11
ExerciseEnhances gut microbiome diversity and stimulates the production of SCFAs in the gastrointestinal tract promoting a diverse microbiome.13
SleepDisruptions can lead to imbalances in the gut microbiome14
StressCan disrupt the gut microbiome and the gut-brain axis11
Table: Factors Affecting Gut Health

Maintaining gut health is not just about what you eat. It’s a holistic approach that involves a balanced diet, regular exercise, adequate sleep, and stress management.

By understanding the factors that affect gut health, you can make informed decisions to improve your gut health and overall well-being.

Dietary Strategies for Gut Health Improvement

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The Importance of a Diverse, Fiber-Rich Diet:

A diverse diet is paramount for maintaining a balanced gut microbiome. The variety ensures that different bacterial species receive their preferred nutrients, promoting a harmonious gut environment15.

Benefits of Dietary Fiber:

  • Nourishment for Gut Bacteria: Dietary fiber serves as food for beneficial gut bacteria, which ferment it into short-chain fatty acids (SCFAs). These SCFAs play a crucial role in maintaining gut health15.
  • Regulation of Digestion: Fiber aids in regular bowel movements, preventing constipation and promoting overall digestive health16.
  • Protection Against Diseases: A fiber-rich diet can reduce the risk of diseases like colorectal cancer and inflammatory bowel disease16.
What are short-chain fatty acids?

Short-chain fatty acids (SCFAs) are fatty acids with fewer than six carbon atoms. They are produced when dietary fiber is fermented in the colon and play a key role in gut health.

Highlighting Probiotic and Prebiotic Foods:

Probiotics and prebiotics are essential components of a gut-friendly diet.

Probiotics: As mentioned, these are live beneficial bacteria that can positively influence gut health17. Adding a probiotic supplement to your daily routine can help maintain a healthy balance of gut bacteria and improve digestion.

  • Sources: Yogurt, kefir, miso, and certain aged cheeses.
  • Benefits: Enhance gut microbiome diversity, improve digestion, and boost the immune system17.

Prebiotics: Non-digestible food components that feed the beneficial bacteria in the gut15.

  • Sources: Onions, garlic, leeks, asparagus, and bananas.
  • Benefits: Support the growth of beneficial bacteria, promote SCFA production, and improve gut barrier15.

The Role of Fermented Foods in Gut Health:

Fermented foods have been consumed for centuries due to their health benefits and preservation properties.

  • Natural Probiotics: Fermented foods are rich in natural probiotics that can enhance the gut microbiome’s diversity18.
  • Production of Beneficial Compounds: The fermentation process produces vitamins, peptides, and neurotransmitters beneficial for gut health18.
  • Examples of Fermented Foods: Kimchi, sauerkraut, tempeh, kombucha, and pickles.

Dietary Strategies for Gut Health

Dietary ComponentSourcesBenefits
Dietary FiberWhole grains, fruits, vegetablesNourishes gut bacteria, regulates digestion, reduces disease risk1516
ProbioticsYogurt, kefir, misoEnhances gut microbiome, improves digestion, boosts immunity17
PrebioticsOnions, garlic, bananasSupports beneficial bacteria, promotes SCFA production15
Fermented FoodsKimchi, kombucha, sauerkrautNatural probiotics, produces beneficial compounds18
Table: Dietary Strategies for Gut Health

Diet plays a pivotal role in gut health improvement. By incorporating a diverse, fiber-rich diet and emphasizing the consumption of probiotics, prebiotics, and fermented foods, one can create a conducive environment for a thriving gut microbiome.

This not only ensures optimal digestion but also paves the way for overall health and well-being.

Lifestyle Changes for Better Gut Health

healthy couple running through a park

The Importance of Regular Exercise for Gut Health:

Engaging in regular physical activity is not only beneficial for cardiovascular health, weight management, and mental well-being but also plays a pivotal role in maintaining a healthy gut microbiome19.

Benefits of Exercise on Gut Health:

  • Diversity Enhancement: Regular exercise can increase the diversity of gut bacteria, which is often linked to better gut health19.
  • Promotion of Beneficial Bacteria: Physical activity can promote the growth of bacteria that produce short-chain fatty acids, beneficial compounds for gut health19.
  • Reduction in Inflammatory Markers: Exercise can reduce systemic inflammatory markers, which can benefit individuals with gut-related issues19.
Regular exercise has many benefits
  1. Heart Health: It lowers heart disease risk.
  2. Weight Control: It burns calories for weight management.
  3. Strength: It builds stronger muscles and bones.
  4. Mental Wellness: It reduces stress and improves sleep.
  5. Energy: It boosts overall endurance.
  6. Brain Health: It enhances cognition and slows decline.
  7. Longevity: It can extend lifespan.

How Good Sleep Hygiene Supports Gut Health:

Quality sleep is intricately linked to gut health. Sleep disturbances can lead to changes in the gut microbiome, potentially leading to gastrointestinal issues20.

Benefits of Proper Sleep on Gut Health:

  • Balanced Gut Microbiome: Consistent sleep patterns can help maintain a balanced gut microbiome20
  • Reduced Risk of Gastrointestinal Disorders: Proper sleep hygiene can decrease the risk of developing gastrointestinal disorders20.
  • Improved Digestive Rhythm: A regular sleep-wake cycle can help regulate the body’s digestive rhythm21.
What are our sleep Cycles?

Sleep has two parts:

  1. Non-REM: Light sleep (N1, N2) and deep sleep (N3) for body repair.
  2. REM: Dreaming and memory processing occur here.

These parts cycle all night.

Stress Management Techniques for Gut Health:

Chronic stress can have detrimental effects on the gut, leading to imbalances in the gut microbiome and increased gut permeability22

Benefits of Stress Management on Gut Health:

  • Improved Gut Barrier Function: Managing stress can help maintain the integrity of the gut barrier22.
  • Balanced Gut Microbiome: Reduced stress levels can lead to a more balanced gut microbiome22.
  • Decreased Inflammation: Effective stress management can reduce inflammation in the gut22.

Lifestyle Strategies for Gut Health

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Regular Exercise

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Good Sleep Hygiene

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Stress Management

Lifestyle ComponentBenefits
Regular ExerciseEnhances gut microbiome diversity, promotes beneficial bacteria, reduces inflammation19
Good Sleep HygieneBalances gut microbiome, reduces risk of GI disorders, improves digestive rhythm20
Stress ManagementImproves gut barrier function, balances gut microbiome, decreases inflammation22
Table: Lifestyle Strategies for Gut Health

Lifestyle factors play a significant role in gut health improvement. By incorporating regular exercise, maintaining good sleep hygiene, and managing stress effectively, one can create a conducive environment for a thriving gut microbiome.

These changes not only ensure optimal digestion but also pave the way for overall health and well-being.

Addressing Common Gut Health Concerns

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Common Symptoms of Poor Gut Health

Recognizing the signs of an unhealthy gut is the first step towards improving your gut health. Some common symptoms include:

  • Digestive Issues: Persistent issues such as gas, bloating, constipation, or diarrhea can indicate an imbalance in your gut microbiome23.
  • Unexplained Weight Changes: Unexpected weight loss or gain without changes in your diet or exercise routine could be a sign of gut health issues24.
  • Constant Fatigue: Poor gut health can interfere with the absorption of nutrients from your food, leading to constant fatigue25.
  • Skin Irritations: Conditions like eczema may be related to a damaged gut26.
  • Autoimmune Conditions: An unhealthy gut can increase systemic inflammation and alter the proper functioning of the immune system, which can lead to autoimmune diseases27.

When to See a Healthcare Professional

While everyone experiences digestive discomfort occasionally, persistent symptoms should not be ignored. It’s important to consult a healthcare professional if you experience:

  • Persistent Digestive Discomfort: If symptoms such as bloating, gas, constipation, or diarrhea persist for more than a few days, it’s time to see a healthcare professional28.
  • Unexplained Weight Changes: Sudden weight loss or gain without changes in diet or exercise habits should be investigated29.
  • Blood in Stool: This can be a sign of a serious condition and should always be evaluated by a healthcare professional30.
  • Severe Abdominal Pain: If you experience severe, persistent abdominal pain, seek immediate medical attention31.

The Role of Medications and Supplements in Gut Health

While lifestyle and dietary changes are the cornerstones of gut health improvement, certain medications and supplements can also play a role:

  • Probiotics: These beneficial bacteria can help restore the natural balance of your gut microbiome32.
  • Prebiotics: The types of dietary fiber that feed the friendly bacteria in your gut33.
  • Antibiotics: These medications can disrupt your gut microbiome by killing both harmful and beneficial bacteria. They should be used judiciously and only when prescribed by a healthcare professional34.

Remember, it’s always best to consult with a healthcare professional before starting any new medication or supplement regimen.

Maintaining good gut health is crucial for your overall well-being. A balanced diet, regular exercise, adequate sleep, and effective stress management can all contribute to a healthier gut.

Remember, small changes can make a big difference over time. So, start today and take steps towards improving your gut health and, in turn, your overall well-being.

Final Thoughts: The Path to Optimal Gut Health and Overall Well-being

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As we’ve journeyed through the intricacies of gut health, it’s evident that our gut is not just a digestive organ but a cornerstone of our overall health.

The myriad of bacteria residing in our gut, collectively known as the gut microbiome, plays a pivotal role in our well-being, influencing everything from digestion to our immune system and even our mood35.

The Centrality of Gut Health

Our gut, the “second brain” has extensive neural networks and constantly communicates with the brain.

This bi-directional communication, known as the gut-brain axis, underscores the importance of a healthy gut for cognitive function and emotional well-being36.

Moreover, an imbalanced gut microbiome, known as dysbiosis, has been linked to a plethora of health issues, including inflammatory bowel diseases, allergies, and even metabolic disorders37.

Taking Action for a Healthier Gut

While the complexity of the gut microbiome can seem daunting, the steps to improve its health are within reach.

Simple dietary changes, incorporating probiotics and prebiotics, managing stress, and maintaining an active lifestyle can all contribute to a balanced gut microbiome38.

Remember, every small change can have a ripple effect, leading to significant improvements in gut health over time.

Gut Health: A Reflection of Overall Well-being

In conclusion, our gut health is a mirror reflecting our overall health. A balanced gut can lead to enhanced immunity, better nutrient absorption, improved mood, and a reduced risk of chronic diseases39.

As you embark on your journey to improve your gut health, know that you’re not just nurturing your digestive system but investing in your holistic well-being.

By prioritizing your gut health, you’re taking a proactive step towards a healthier, more vibrant life.

Embrace the journey, celebrate the small victories, and remember that every effort you make towards gut health improvement is a step towards a healthier, happier you.

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Frequently Asked Questions

There are numerous ways to improve your gut health. These include eating a varied diet rich in fiber, consuming probiotic and prebiotic foods, limiting the intake of ultra-processed foods and antibiotics, ensuring adequate sleep, and managing stress. All these habits contribute to a robust and resilient gut microbiome.

Yes, probiotic foods such as yogurt, kefir, sauerkraut, and kimchi, contain live bacteria that contribute to a healthy gut. They can add to the diversity of gut microbes, which plays a key role in many aspects of health including digestion, immunity, and even mood regulation.

Gut health is closely linked to overall health. The gut microbiome, also known as your gut microbiome, plays essential roles in digestion, nutrient absorption, immune function, and even mood regulation. A healthy gut can contribute to better overall health and wellbeing, while an unhealthy gut can lead to various health problems.

Some science-backed ways to support gut health include eating a diverse range of whole foods, consuming probiotic foods, staying hydrated, getting regular exercise, getting enough sleep, and managing stress. These lifestyle changes can have a positive impact on gut health and overall wellbeing.

Both probiotic and prebiotic foods have a positive impact on your gut microbiome. Probiotic foods contain beneficial bacteria that can boost the health of your gut, while prebiotic foods provide fiber that nourishes these beneficial bacteria in the gut. Incorporating both into your diet can support a healthy gut ecosystem.

Fermented foods are a natural source of probiotics, the type of bacteria that benefits gut health. They can help increase the diversity of gut microbes, contributing to a healthy balance in the digestive tract. Fermented foods you eat, like yogurt, sauerkraut, and kimchi, are excellent for improving your gut health naturally.

Common symptoms of an unhealthy gut can include digestive discomfort, such as bloating or irritable bowel syndrome (IBS), fatigue, skin problems, and unexplained weight changes. An unhealthy gut may also increase the risk of certain health issues like type 2 diabetes, heart health issues, and aspects of health and stress relations.

Antibiotics can negatively impact your gut health as they kill not only harmful bacteria but also the healthy bacteria in your gut. This can disrupt the balance of the gut flora and potentially lead to digestive issues. It’s important to take probiotics and eat prebiotic-rich whole foods after a course of antibiotics to replenish the healthy bacteria.

: Fruits and vegetables are rich in fiber, which is an essential nutrient for the gut microbes. These plant foods are digested by these species of bacteria in the gut, producing beneficial compounds that help support a healthy gut. People who eat a diverse diet rich in whole plant foods tend to have a healthier gut microbiome.

Yes, certain foods can negatively impact your gut health. Ultra-processed foods, in particular, are often low in fiber and high in additives and sugar, which can disrupt the balance amongst gut microbes. These foods may also increase the risk of negative health impacts such as strains of bacteria associated with disease.

References

  1. Lozupone CA, Stombaugh JI, Gordon JI, Jansson JK, Knight R. Diversity, stability and resilience of the human gut microbiota. Nature. 2012;489(7415):220-230. doi:10.1038/nature11550
  2. Zhang H, Liao X, Sparks JB, Luo XM. Dynamics of gut microbiota in autoimmune lupus. Appl Environ Microbiol. 2014;80(24):7551-7560. doi:10.1128/AEM.02676-14
  3. McCabe L, Britton RA, Parameswaran N. Prebiotic and Probiotic Regulation of Bone Health: Role of the Intestine and its Microbiome. Curr Osteoporos Rep. 2015;13(6):363-371. doi:10.1007/s11914-015-0292-x
  4. Hasan N, Yang H. Factors affecting the composition of the gut microbiota, and its modulation. PeerJ. 2019;7:e7502. Published 2019 Aug 16. doi:10.7717/peerj.7502
  5. Dimitriu PA, Iker B, Malik K, Leung H, Mohn WW, Hillebrand GG. New Insights into the Intrinsic and Extrinsic Factors That Shape the Human Skin Microbiome. mBio. 2019;10(4):e00839-19. Published 2019 Jul 2. doi:10.1128/mBio.00839-19
  6. Ursell LK, Metcalf JL, Parfrey LW, Knight R. Defining the human microbiome. Nutr Rev. 2012;70 Suppl 1(Suppl 1):S38-S44. doi:10.1111/j.1753-4887.2012.00493.x
  7. Ma Y, Xu X, Li M, Cai J, Wei Q, Niu H. Gut microbiota promote the inflammatory response in the pathogenesis of systemic lupus erythematosus. Mol Med. 2019;25(1):35. Published 2019 Aug 1. doi:10.1186/s10020-019-0102-5
  8. McCabe L, Britton RA, Parameswaran N. Prebiotic and Probiotic Regulation of Bone Health: Role of the Intestine and its Microbiome. Curr Osteoporos Rep. 2015;13(6):363-371. doi:10.1007/s11914-015-0292-x
  9. Pickard JM, Zeng MY, Caruso R, Núñez G. Gut microbiota: Role in pathogen colonization, immune responses, and inflammatory disease. Immunol Rev. 2017;279(1):70-89. doi:10.1111/imr.12567
  10. Everard A, Cani PD. Diabetes, obesity and gut microbiota. Best Pract Res Clin Gastroenterol. 2013;27(1):73-83. doi:10.1016/j.bpg.2013.03.007
  11. Deledda A, Annunziata G, Tenore GC, Palmas V, Manzin A, Velluzzi F. Diet-Derived Antioxidants and Their Role in Inflammation, Obesity and Gut Microbiota Modulation. Antioxidants (Basel). 2021;10(5):708. Published 2021 Apr 29. doi:10.3390/antiox10050708
  12. Brown K, DeCoffe D, Molcan E, Gibson DL. Diet-induced dysbiosis of the intestinal microbiota and the effects on immunity and disease [published correction appears in Nutrients. 2012 Oct;4(11)1552-3]. Nutrients. 2012;4(8):1095-1119. doi:10.3390/nu4081095
  13. Strasser B, Wolters M, Weyh C, Krüger K, Ticinesi A. The Effects of Lifestyle and Diet on Gut Microbiota Composition, Inflammation and Muscle Performance in Our Aging Society. Nutrients. 2021;13(6):2045. Published 2021 Jun 15. doi:10.3390/nu13062045
  14. Wickham SR, Amarasekara NA, Bartonicek A, Conner TS. The Big Three Health Behaviors and Mental Health and Well-Being Among Young Adults: A Cross-Sectional Investigation of Sleep, Exercise, and Diet. Front Psychol. 2020;11:579205. Published 2020 Dec 10. doi:10.3389/fpsyg.2020.579205
  15. Deledda A, Annunziata G, Tenore GC, Palmas V, Manzin A, Velluzzi F. Diet-Derived Antioxidants and Their Role in Inflammation, Obesity and Gut Microbiota Modulation. Antioxidants (Basel). 2021;10(5):708. Published 2021 Apr 29. doi:10.3390/antiox10050708
  16. Macfarlane GT, Macfarlane S. Bacteria, colonic fermentation, and gastrointestinal health. J AOAC Int. 2012;95(1):50-60. doi:10.5740/jaoacint.sge_macfarlane
  17. Collado MC, Isolauri E, Salminen S, Sanz Y. The impact of probiotic on gut health. Curr Drug Metab. 2009;10(1):68-78. doi:10.2174/138920009787048437
  18. Quigley EMM. Prebiotics and Probiotics in Digestive Health. Clin Gastroenterol Hepatol. 2019;17(2):333-344. doi:10.1016/j.cgh.2018.09.028
  19. Dobrosielski DA, Papandreou C, Patil SP, Salas-Salvadó J. Diet and exercise in the management of obstructive sleep apnoea and cardiovascular disease risk. Eur Respir Rev. 2017;26(144):160110. Published 2017 Jun 28. doi:10.1183/16000617.0110-2016
  20. Matenchuk BA, Mandhane PJ, Kozyrskyj AL. Sleep, circadian rhythm, and gut microbiota. Sleep Med Rev. 2020;53:101340. doi:10.1016/j.smrv.2020.101340
  21. Vernia F, Di Ruscio M, Ciccone A, et al. Sleep disorders related to nutrition and digestive diseases: a neglected clinical condition. Int J Med Sci. 2021;18(3):593-603. Published 2021 Jan 1. doi:10.7150/ijms.45512
  22. Chakaroun RM, Massier L, Kovacs P. Gut Microbiome, Intestinal Permeability, and Tissue Bacteria in Metabolic Disease: Perpetrators or Bystanders?. Nutrients. 2020;12(4):1082. Published 2020 Apr 14. doi:10.3390/nu12041082
  23. Thursby E, Juge N. Introduction to the human gut microbiota. Biochem J. 2017;474(11):1823-1836. Published 2017 May 16. doi:10.1042/BCJ20160510
  24. Turnbaugh PJ, Ley RE, Mahowald MA, Magrini V, Mardis ER, Gordon JI. An obesity-associated gut microbiome with increased capacity for energy harvest. Nature. 2006;444(7122):1027-1031. doi:10.1038/nature05414.
  25. Foster JA, McVey Neufeld KA. Gut-brain axis: how the microbiome influences anxiety and depression. Trends Neurosci. 2013;36(5):305-312. doi:10.1016/j.tins.2013.01.005
  26. Salem I, Ramser A, Isham N, Ghannoum MA. The Gut Microbiome as a Major Regulator of the Gut-Skin Axis. Front Microbiol. 2018;9:1459. Published 2018 Jul 10. doi:10.3389/fmicb.2018.01459
  27. Fung TC, Olson CA, Hsiao EY. Interactions between the microbiota, immune and nervous systems in health and disease. Nat Neurosci. 2017;20(2):145-155. doi:10.1038/nn.4476
  28. Camilleri M. Leaky gut: mechanisms, measurement and clinical implications in humans. Gut. 2019;68(8):1516-1526. doi:10.1136/gutjnl-2019-318427
  29. Turnbaugh PJ, Gordon JI. The core gut microbiome, energy balance and obesity. J Physiol. 2009;587(Pt 17):4153-4158. doi:10.1113/jphysiol.2009.174136
  30. Cani PD, de Vos WM. Next-Generation Beneficial Microbes: The Case of Akkermansia muciniphila. Front Microbiol. 2017;8:1765. Published 2017 Sep 22. doi:10.3389/fmicb.2017.01765
  31. Mayer EA, Tillisch K, Gupta A. Gut/brain axis and the microbiota. J Clin Invest. 2015;125(3):926-938. doi:10.1172/JCI76304
  32. Hill C, Guarner F, Reid G, et al. Expert consensus document. The International Scientific Association for Probiotics and Prebiotics consensus statement on the scope and appropriate use of the term probiotic. Nat Rev Gastroenterol Hepatol. 2014;11(8):506-514. doi:10.1038/nrgastro.2014.66
  33. Manning TS, Gibson GR. Microbial-gut interactions in health and disease. Prebiotics. Best Pract Res Clin Gastroenterol. 2004;18(2):287-298. doi:10.1016/j.bpg.2003.10.008
  34. Francino MP. Antibiotics and the Human Gut Microbiome: Dysbioses and Accumulation of Resistances. Front Microbiol. 2016;6:1543. Published 2016 Jan 12. doi:10.3389/fmicb.2015.01543
  35. Foster JA, Baker GB, Dursun SM. The Relationship Between the Gut Microbiome-Immune System-Brain Axis and Major Depressive Disorder. Front Neurol. 2021;12:721126. Published 2021 Sep 28. doi:10.3389/fneur.2021.721126
  36. Carabotti M, Scirocco A, Maselli MA, Severi C. The gut-brain axis: interactions between enteric microbiota, central and enteric nervous systems. Ann Gastroenterol. 2015;28(2):203-209.
  37. Petersen C, Round JL. Defining dysbiosis and its influence on host immunity and disease. Cell Microbiol. 2014;16(7):1024-1033. doi:10.1111/cmi.12308
  38. Olvera-Rosales LB, Cruz-Guerrero AE, Ramírez-Moreno E, et al. Impact of the Gut Microbiota Balance on the Health-Disease Relationship: The Importance of Consuming Probiotics and Prebiotics. Foods. 2021;10(6):1261. Published 2021 Jun 2. doi:10.3390/foods10061261
  39. Zhang P. Influence of Foods and Nutrition on the Gut Microbiome and Implications for Intestinal Health. Int J Mol Sci. 2022;23(17):9588. Published 2022 Aug 24. doi:10.3390/ijms23179588
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